Both are 57-degree vertical wireless mice designed to encourage a handshake grip, reduce wrist pressure, and support a more natural forearm posture during desk work. Both also take some adjustment if you are used to a standard mouse.
The deciding difference is fit. Lift is explicitly shaped for small to medium right hands and pairs over Bluetooth or a Logi Bolt receiver. MX Vertical is the larger, taller mouse; it also connects over Bluetooth, adds its included USB receiver and a wired USB-C option, and lists 4000 DPI tracking with a cursor-speed switch. Lift specifies quiet clicks, while MX Vertical emphasizes its pronounced thumb rest.

Logitech MX Vertical Wireless Ergonomic Mouse
Best for Best for wrist comfort
A tall, sculpted wireless mouse built around a handshake-style grip. It suits desk users who prioritize wrist posture over portability or instant familiarity.
- + Handshake-style grip with a listed 57-degree vertical angle
- + 4000 DPI optical tracking with a cursor-speed switch
- + Textured surface and pronounced thumb rest
- − Vertical shape requires an adjustment period
- − Tall body is less convenient for travel
Full review
Logitech Lift Vertical Ergonomic Wireless Mouse
Best for Best for quiet offices and calls
A quiet vertical mouse shaped for small to medium right hands, with Bluetooth or Logi Bolt connectivity and a more natural forearm position.
- + Comfort-focused 57-degree vertical shape
- + Well suited to small and medium right hands
- + Quiet clicks for shared workspaces
- − Not a good fit for large hands
- − Right-handed shape excludes left-handed users
Full review